Visible Man

Pioneering Pharma of the Future℠ .

Do you feel that? It’s the industry changing. And no one has a finger on the pulse of drug development like our fearless leader Ted Grasela. So we thought, hey, let’s give him an outlet to share his wisdom. And so the Cognigen blog was born. Check back here often for insightful articles, unique views on industry trends, and a whole lot more on the evolution of this critical field.

October 3, 2015

Conceptual Schemas

Category: Pharma Of The Future,

The central focus of MBR&D is not the mathematical equations but rather the conceptual synthesis process that integrates all available information and rational extrapolations to better understand drug pharmacology in the context of the disease process. The outcome of this synthesis process is a conceptual schema, a term borrowed from database design. The schema represents a series of assertions about the nature of the disease process and drug pharmacology. It describes the entities of significance to a research program, their characteristics or attributes, and the relationships between pairs of entities thought to be significant.


October 12, 2014

History of Pharma of the Future

Category: Pharma Of The Future,

Pharmacometric modeling and simulation has moved from its infancy as a novel way of approaching the analysis of clinical pharmacokinetic data to become an invaluable tool in pharmaceutical and biotechnology research and development. Early, tentative applications of modeling have given way to robust model-based drug development activities in which pharmacokinetic and pharmacodynamic modeling and simulation results are widely utilized to improve the probability of successful clinical trials. Pharma of the Future Historical Time Line


December 12, 2013

The value of a conceptual schema.

Category: Knocked My Socks Off,

A worthwhile podcast highlighting the value of a conceptual schema.