Visible Man

Pioneering Pharma of the Future℠ .

Do you feel that? It’s the industry changing. And no one has a finger on the pulse of drug development like our fearless leader Ted Grasela. So we thought, hey, let’s give him an outlet to share his wisdom. And so the Cognigen blog was born. Check back here often for insightful articles, unique views on industry trends, and a whole lot more on the evolution of this critical field.

April 16, 2016

Global Health Initiative

Category: Pharma Of The Future,

Envisioned by Cognigen Corporation, a Simulations Plus (Nasdaq:SLP) company, in 2003, the Pharma of the FutureSM (PoF) program was conceived as a research and training initiative to design and implement the workflows and computer systems required to support modeling and simulation (M&S) activities. The numerous M&S projects performed by Cognigen scientists became a source of raw material for research initiatives designed to improve the quality, timeliness, and impact of M&S results. These research initiatives have yielded numerous benefits, including:

  • Formalized data definitions and data programming requirements that enable the timely delivery of quality data for analysis
  • A robust informatic infrastructure and computer system which became the foundation for the KIWITM platform
  • A variety of internally and externally focused training programs to advance the science and technology required for planning, executing, and reporting M&S efforts
  • Click here for more information about the PoF program.

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March 9, 2016

A historical perspective from Alison Boeckmann

Category: Pharma Of The Future,

Postscript:

All of us in the pharmacometrics community owe a debt of gratitude to Lewis, Stuart, Alison, and the many others who were involved in the development of NONMEM. The program has proven to be of tremendous value in dealing with the challenges we encounter in pharmaceutical research and development. NONMEM has truly changed the landscape and – really – we are only at the beginning of a new era of model-driven R&D.

A historical perspective from Alison Boeckmann – One of the developers and programmers of NONMEM

Reprinted here with Alison’s permission

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October 3, 2015

Conceptual Schemas

Category: Pharma Of The Future,

The central focus of MBR&D is not the mathematical equations but rather the conceptual synthesis process that integrates all available information and rational extrapolations to better understand drug pharmacology in the context of the disease process. The outcome of this synthesis process is a conceptual schema, a term borrowed from database design. The schema represents a series of assertions about the nature of the disease process and drug pharmacology. It describes the entities of significance to a research program, their characteristics or attributes, and the relationships between pairs of entities thought to be significant.

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