Celebration

Pioneering Pharma of the Future℠ .

Do you feel that? It’s the industry changing. And no one has a finger on the pulse of drug development like our fearless leader Ted Grasela. So we thought, hey, let’s give him an outlet to share his wisdom. And so the Cognigen blog was born. Check back here often for insightful articles, unique views on industry trends, and a whole lot more on the evolution of this critical field.

January 20, 2010

Intro to Pharma of the Future™

The pharma industry has a critical need to establish model-based drug development. The Pharma of the Future™ (PoF) program is a research initiative to support this important enterprise transformation.

READ MORE


November 17, 2009

An Uncommon Vignette?

Tired of late-stage development failures, the CEO of a pharmaceutical company decides to act on the promise of pharmacometrics. “Fix it,” he says to the head of clinical pharmacology, “I don’t care what it takes!”

READ MORE


October 27, 2009

Square Pegs in Round Holes?

A crusading scientist identifies a potential public health threat and uses the internet to get access to a cache of data from several studies. Sound like the plot of a new medical thriller?

READ MORE


September 11, 2009

Kerfuffle! (pt 3)

A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that seem to gain in severity and impact. Formalization of the pharmacometrics process, and the definition of process maps for the key tasks invoked in modeling and simulation activities, can prevent kerfuffles.

READ MORE


February 17, 2009

Kerfuffle! (pt 2)

A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that seem to gain in severity and impact. But where do kerfuffles come from and how do we prevent them from happening?

READ MORE


November 7, 2008

Kerfuffle! (pt 1)

\kәr-’fә-fәl\ to become disheveled. A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that gain in severity and impact. This essay describes a strategy for eradicating or minimizing the impact of kerfuffles in pharmacometrics.

READ MORE