January 20, 2010
Intro to Pharma of the Future™
The pharma industry has a critical need to establish model-based drug development. The Pharma of the Future™ (PoF) program is a research initiative to support this important enterprise transformation.
November 17, 2009
An Uncommon Vignette?
Tired of late-stage development failures, the CEO of a pharmaceutical company decides to act on the promise of pharmacometrics. “Fix it,” he says to the head of clinical pharmacology, “I don’t care what it takes!”
October 27, 2009
Square Pegs in Round Holes?
A crusading scientist identifies a potential public health threat and uses the internet to get access to a cache of data from several studies. Sound like the plot of a new medical thriller?
September 11, 2009
Kerfuffle! (pt 3)
A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that seem to gain in severity and impact. Formalization of the pharmacometrics process, and the definition of process maps for the key tasks invoked in modeling and simulation activities, can prevent kerfuffles.
February 17, 2009
Kerfuffle! (pt 2)
A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that seem to gain in severity and impact. But where do kerfuffles come from and how do we prevent them from happening?
November 7, 2008
Kerfuffle! (pt 1)
\kәr-’fә-fәl\ to become disheveled. A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that gain in severity and impact. This essay describes a strategy for eradicating or minimizing the impact of kerfuffles in pharmacometrics.