[NMusers] NONMEM Intermediate Workshop by Uppsalla Univ 25-27/04/06 in Marseille

Uppsalla University (Sweden)

and non-profit association AP²POP are please to announce the =
organisation of:

NONMEM intermediate workshop:

New features and advanced methods for model building and evaluation in =
NONMEM VI

Marseille, France, 25th, 26th and 27th April 2007
Overview

The pharmacometrics group at Uppsala University has been involved in =
developing NONMEM models and methodology for over fifteen years. We =
have been involved in the testing and evaluation of NONMEM VI as it has =
been developed during the last decade. Several research projects have =
focused on new functionality in NONMEM VI. In parallel, diagnostics for =
model building have been developed, evaluated and integrated into NONMEM =
VI-adapted versions of the programs Perl-speaks-NONMEM (PsN) and Xpose 4 =
(described below). In this course we will present some of the most =
exciting new features of NONMEM VI and how these tools can be used in =
the development and evaluation of non-linear mixed effects models.

  
Agenda (3 full days)

The course will last for 3 days and consists of both lectures and =
hands-on computer exercises. Participants will use NONMEM VI, PsN and =
Xpose 4. PsN and Xpose 4 are freeware and may be installed on =
participants’ computers for use after the course. In addition to the =
agenda below consultation sessions will be offered during each day of =
the course.

 

    * Day 1 – New features of NONMEM VI
          o General overview
          o The use of prior information on parameter values in NONMEM =
evaluations
          o Using nonparametric parameter estimation in model building =
using NONMEM
          o Handling data below the limit of quantification (BLQ)
          o Hands-on computer exercises

 

    * Day 2 - Model building and diagnostics using NONMEM VI
          o Model evaluation in the literature
          o Improved model evaluation: Using XPOSE 4 with NONMEM VI
                + Conditional weighted residuals
                + Shrinkage-corrected Empirical Bayes based diagnostics
                + Simulation based diagnostic references
                + Individual objective function contributions
                + Non-parametric distribution visualization
          o Hands-on computer exercises with Xpose

 

    * Day 3 – Advanced model building and diagnostics using Perl =
Speaks NONMEM (PsN)
          o Automation of NONMEM VI runs
          o Bootstrapping
          o Case deletion diagnostics
          o Visual and numerical predictive checks
          o Hands-on computer exercises

Prerequisite

Having used NONMEM and understanding population PK-PD modelling

And/or having attended a NONMEM basic workshop


Instructors

Prof. Mats Karlsson

Mats Karlsson is professor of Pharmacometrics at Uppsala University, =
Sweden where he leads a research group of about twenty modellers. He =
received his PhD in pharmacokinetics from this university in 1989 and =
has been a research fellow at University of Glasgow and University of =
California, San Francisco, and a visiting professor at Georgetown =
University, Washington DC. He has received the Giorgio Segre Prize from =
EUFEPS and is editor for the Journal of Pharmacokinetics and =
Pharmacodynamics. His research interests focus on methodological aspects =
of non-linear mixed effects model building and applied PKPD modelling. =
He has published over one hundred original research articles in the area =
of PK and PKPD.


Dr Andrew Hooker

Andrew Hooker is an assistant professor of pharmacometrics at Uppsala =
University, Sweden. Andrew received his PhD in Bioengineering from the =
University of Washington, Seattle, USA in 2003, and then moved to Sweden =
as a Pfizer post-doctoral fellow at Uppsala University. His research =
focuses on methodological problems associated with building and =
evaluating pharmacometric models as well as population optimal =
experimental design for non-linear mixed effects models. Andrew is a =
primary developer of both Xpose 4 and the population optimal =
experimental design program PopED.


Dr Lars Lindbom

Lars Lindbom is a researcher in Pharmacometrics at Uppsala University, =
Sweden. He received his PhD in pharmacokinetics and drug therapy from =
Uppsala University in 2006. He is leading the development of =
Perl-speaks-NONMEM.


Dr Radojka Savic

Rada Savic joined the Pharmacometric research group at Uppsala =
University, Sweden in 2003 after receiving her pharmacist degree from =
University of Belgrade, Serbia. Since then, she has been actively =
working on evaluating new features of NONMEM VI. Her research interests =
focus on nonparametric methods for population analysis, improved =
diagnostics for NONMEM VI and development of new absorption models.

 

Technical Assistance: Pontus Pihlgren

 
Details

The course will emphasize hands on training, with the participants =
working on their own computers or using a computer on-site. =
Participants choosing to bring their own computers will run all programs =
from an USB memory-stick and will not be required to install any =
programs on their computer. Participants are encouraged to bring their =
own data sets and NONMEM models to work with during the hands-on =
sessions.



Xpose 4 is a model building aid for population analysis using NONMEM. It =
facilitates data set checkout, exploration and visualization, model =
diagnostics, candidate covariate identification and model comparison. =
Xpose 4 has been rewritten in the programming language R with a modular =
and object oriented design allowing for integration into nearly any =
model building platform. New functionality in Xpose 4 allows the user =
to create simulation based reference diagnostics, compute the =
conditional weighted residuals and modify standard Xpose graphics to =
create publication quality figures. Xpose 4 also makes use of the new =
features in NONMEM VI allowing for the visualization of non-parametric =
parameter distributions and individual objective function contributions. =
 Freely available at xpose.sf.net.


Perl-speaks-NONMEM (PsN) is a collection of Perl modules and programs =
aiding in the development of non-linear mixed effect models using =
NONMEM. The functionality ranges from simpler tasks such as parameter =
estimate extraction from output files, data file sub setting and =
resampling, to advanced computer-intensive statistical methods. PsN =
includes both stand-alone tools as well as development libraries for =
method developers. Freely available at psn.sf.net.


Registration Fees, VAT included:

          Industry: 1700 EUROS Reduced fees for Academic: =
1200 EUROS

Registration fees include: syllabus; 1 computer for 2 participants =
loaded with all software; morning and afternoon refreshment breaks and =
lunches on Wednesday to Friday. Gala dinner.

 

==> Attendance is strictly limited to 40.

==> Number of “reduced fees” for Academics and students is =
limited.

==> Registration and academic fees will be offered on the basis of =
first come, first served

==> Participants have the choice to bring their own laptop. In in =
this case they will run all programs from an USB memory-stick and will =
not be required to install any programs on their computer. =
Participants are encouraged to bring their own data sets and NONMEM =
models to work with during the hands-on sessions.



Hotel Workshop and City:

Novotel Marseille Vieux Port

36, Boulevard Charles Livon, 13007 MARSEILLE, FRANCE

Tel : (+33) 496 11 42 11 ; Fax : (+33) 496 11 42 20; E-mail : =
H0911_at_accor.com

http://www.novotel.com/novotel/fichehotel/gb/nov/0911/fiche_hotel.shtml

Located in the heart of the city, the hotel overlooks the world famous =
Old Harbour. It is situated in a green environment with panoramic =
terrace and stunning views. The City of Marseille overlooks the =
Mediterranean Sea. As the capital of the third economic region of France =
and the first industrial and services pole of the south of France, it =
can easily be reached by plane, train (high speed connection from Lyon =
or Paris), freeway or even … boat.

 

Workshop Organising Committee:

Silvy Laporte, Medical University, Saint Etienne =
silvy.laporte_at_chu-st-etienne.fr

Pascal Girard, INSERM, EA3738 Lyon I University =
Pascal.Girard_at_adm.univ-lyon1.fr

Brigitte Tranchand CLB, EA3738 Lyon I University =
Brigitte.Tranchand_at_adm.univ-lyon1.fr

Nicolas Simon, EA3784 Medical University, Marseille =
nicolas.simon_at_medecine.univ-mrs.fr

 

REGISTRATION FORM

NONMEM intermediate workshop:

Marseille, France, 25th to 27th April 2007

Registration form

First Name: ………………………………… Family Name: =
...……………………………………..

Institution/Address : =
…………………………………………………………………=
….…………….

…….…………………………………………………………=
……………….…………………………..

Postal Code: …………… City: =
……………………………… Country: =
…...……………….

Tel: …………………… Fax: ………………. Email =
………………………….……………..

Payment

Industry 1700 EUROS o =
Academic/Student 1200 EUROS o

Will bring my own computer o

o Attached check in Euros drawn on a French bank payable to AP2POP

Or

o Bank transfer in Euros to: AP2POP account, Credit Commercial de =
France, Lyon

                                                      Swift code: CCF =
RFRPP
                                                      Bank # 30056 =
                   Agency # 00142
                                                      Account # 0142 540 =
0640 Clef RIB 01
Ø Bank fees are paid by the participant.
Ø In the bank order, give name & institution of participant.

 

Complete and send the form and check to:

 

Silvy Laporte, AP2POP

Unité Pharmacologie Clinique

HOPITAL DE BELLEVUE Pavillon 5

42055 SAINT-ETIENNE CEDEX 02

France


Or fax it to

Fax: +33 4 77 12 78 20

Received on Thu Dec 14 2006 - 16:15:29 EST