In order to extend our body of knowledge of platforms used by our NONMEM
users, we have investigated installation of NONMEM VI on a MacBook Pro.
Much to our delight, it was a relatively easy experience. Essentially,
we followed the Linux installation instructions given in Section III of
the readme_6.1.0.doc found on the NONMEM VI installation CD-ROM with ONE
notable exception. Despite the fact that the MacBook Pro uses an Intel
Core 2 Duo processor, the IEEE machine constants were used and NOT the
Intel machine constants (this can be done by not specifying an argument
for the machine constants as IEEE is the default).
The setup command used was:
./SETUP /opt/nmvi g95 '-O -fsloppy-char' /usr/bin/ar
(This specifies an installation directory of /opt/nmvi, the g95 compiler
using the -O -fsloppy-char optimization options (enclosed in single
quotes), the archive command path and, by default, the IEEE constants.
The "./" before the command is required if your csh shell environment
does not include the current directory, ".", in the PATH variable to
execute any program in the current directory.)
System Specifics:
MacBook Pro 2,2
Intel Core 2 Duo, 2.16 GHz
1 GB Memory
Mac OS X 10.4.8 (Tiger)
Installation and NONMEM runs done using the Mac Terminal Utility
Required additional software:
g95 Fortran compiler (g95-powerpc-osx.tar obtained from
http://ftp.g95.org)
Xcode 2.4.1 Developers Tools (free from Apple)
A particularly helpful website for high performance computing on the Mac
(with respect to computation tools for the Mac) can be found at
http://hpc.sourceforge.net, ). This report represents preliminary
results of our Mac investigations. Additional Mac-related information
will be reported at a later date. Other NONMEM users have reported that
the commercial Intel compiler is also a viable Fortran compiler for the
Mac. Any additional Mac information that other nmusers would like to
share will be greatly appreciated.
William J. Bachman, Ph.D.
Director, Pharmacometrics R&D
Icon Development Solutions
6031 University Blvd., Suite 300
Ellicott City, MD 21043
Office 410-696-3002
Cell 301-467-8635
bachmanw_at_iconus.com
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Received on Thu Dec 21 2006 - 10:26:50 EST
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