[NMusers] Distribution of NONMEM VI

Dear all:

Icon Development Solutions is now distributing NONMEM VI to all
currently licensed sites. During the initial post-distribution period,
if you encounter unexpected results when using NONMEM VI, please contact
me directly at luddent_at_globomaxnm.com or (410) 696-3040.

The transformation of parameters used in the estimation step is
different from that used in NONMEM V; therefore, gradients in the
intermediate output will differ from those in NONMEM VI. Results for
CONTROL3 - 5 examples (provided with the distribution) using NONMEM VI
are available at the NONMEM ftp site
ftp://ftp.globomaxnm.com/Public/nonmem/ in a folder named
StdresultsNONMEMVI.

The conditional estimation of interindividual random terms, ETA's, also
differs. For conditional estimation methods, NONMEM VI is numerically
more stable and frequently provides shorter run-times than NONMEM V.
However, on occasion and with specific problems, NONMEM V may prove to
be useful in finding a stable, minimum objective function.
We encourage all current users to maintain their installation of NONMEM
V while they explore the performance and new features of NONMEM VI. As
long as NONMEM VI is installed into a different directory there will be
no conflict between the two version. If CDSETUP6.bat is used, the
default directory for NONMEM VI is nmvi.

Tom Ludden
Icon Development Solutions





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Received on Thu Nov 30 2006 - 09:34:36 EST