[NMusers] batches with different half-life - linear PK

Hello NONMEM Users,

Sometimes the same subjects receive the same drug from different batches. Potentially, half-life can be different accross batches. Theoretically, it is easy to model if PKis linear because NONMEM superimposes single-dose processes to obtain predicted concentrations for multiple doses. Does enyone know how to implement it in NONMEM? Are there any classes or publications which can help?

Thanks!
Pavel

Received on Thu Apr 19 2007 - 10:54:11 EDT