RE: [NMusers] batches with different half-life - linear PK

Dear,
Just out of curiosity, why would a different batch cause a different
half life?
Are we talking about proteins/large molecules?
Malaz
 

Malaz A. AbuTarif,
B.Sc. (Pharmacy), Ph.D., G.C.P.M., M.B.A.
Principal Scientist, Schering- Plough Research Institute
2015 Galloping Hill Rd, K-15-2-2650
Kenilworth, NJ 07033
Tel: (908) 740-3835, Fax: (908) 740-2916
malaz.abutarif_at_spcorp.com

        -----Original Message-----
        From: owner-nmusers_at_globomaxnm.com
[mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Bachman, William
(MYD)
        Sent: Thursday, April 19, 2007 11:45 AM
        To: nonmem_at_optonline.net; nmusers_at_globomaxnm.com
        Subject: RE: [NMusers] batches with different half-life - linear
PK
        
        
        maybe I am missing something here, but, why don't you
parameterize your model in terms of half-life and put BATCH as a
covariate on half-life?

________________________________

        From: owner-nmusers_at_globomaxnm.com
[mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of nonmem_at_optonline.net
        Sent: Thursday, April 19, 2007 10:54 AM
        To: nmusers_at_globomaxnm.com
        Subject: [NMusers] batches with different half-life - linear PK
        
        
        Hello NONMEM Users,
         
        Sometimes the same subjects receive the same drug from different
batches. Potentially, half-life can be different accross batches.
Theoretically, it is easy to model if PKis linear because NONMEM
superimposes single-dose processes to obtain predicted concentrations
for multiple doses. Does enyone know how to implement it in NONMEM?
Are there any classes or publications which can help?
         
        Thanks!
        Pavel

        
        
        
        
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Received on Thu Apr 19 2007 - 17:39:07 EDT