[NMusers] Model Comparison and Viewing of Output

  Dear NMusers,
   
  I had a couple of questions for the group members:
   
  1. Model Comparison: Everything else remaining the same in a model, should a drop in the objective function on addition of an eta, sigma or a covariance term reflect an improvement in a model. Or comparing AICs, considering eta's and sigma's as additional parameters a correct approach. I understand that these decisions are rather based on multiple criterias like goodness of fit plots, biological sense, physiological plausibility of the parameter estimates etc. But specifically would like to know whether comparing objective function among these models a logical approach?
   
  2. Viewing Output via $TABLE option: When we do simulation using NONMEM,the output file contains both the dosing and observation records. Is there a way in NONMEM to specify a priori in the control stream, such that only observation records could be obtained in the simulation output file?
   
  Thanks and Regards
   
  Nitin Mehrotra


    Nitin Mehrotra, Ph.D
  Post Doctoral Research Fellow
  874 Union Avenue, Suite4.5p/5p
  Department of Pharmaceutical Sciences
  University of Tennessee Health Science Center
  Memphis, TN, USA-38163
  901-448-3385 (Lab)
  nmehrotr_at_utmem.edu
   



       
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Received on Tue Aug 14 2007 - 12:18:56 EDT