RE: [NMusers] error (157) forrtl: severe

Thank you, Mark for responding.

Yes, NONMEM is running often just fine - up to a few hundred function
evaluations. But sometimes it crashes even before I see the first
iteration. When it crashes later I see the entire set of FILEs and
executables in the directory. So NONMEM and NMTRAN were working fine.

But, how do you explain that the same models reformulated with ANDAN6 run?
Well, they take very long... and none of them has run to a successful
minimization yet.

Joachim





Mark Sale - Next Level Solutions <mark_at_nextlevelsolns.com>
07.12.2007 13:44

To
Joachim.Grevel_at_merckserono.net
cc
nmusers_at_globomaxnm.com
Subject
RE: [NMusers] error (157) forrtl: severe








Joachim,
 This is probably a file access error, from Fortan/OS, not from NONMEM.
Does NMTRAN run? Does the compiler run? Does nmlink6 run (do you get
link.lnk)? Do you get an executable? Does NONMEM start then stop? If you
get the executable (nonmem.exe or fsubs.exe), then the error is with file
access in the NONMEM itself. Don't know which file, but if NMTRAN runs it
isn't the (NMTRAN) data set, still could be FDATA, FCON, FSTREAM, FRECORD,
any of the FILE? (but probably not) or an MSF. Fortran should close all
the files when it exits, by any method (e.g., if it crashes). Could
conceivable be a library file from the compiler as well.
Mark


Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185

-------- Original Message --------
Subject: [NMusers] error (157) forrtl: severe
From: Joachim.Grevel_at_merckserono.net
Date: Fri, December 07, 2007 6:19 am
To: nmusers_at_globomaxnm.com


A question for FORTRAN experts:

Fortran Error 157: access violation

is the error we see when NONMEM crashes on our server installation with
models which otherwise run fine on our local PC installations of NONMEM.
These crashes occur with very simple (ADVAN2) and also with rather
complicated (ADVAN5, ADVAN7) models. They can be avoided when models are
reformulated with ADVAN6 TOL=5. Of course with ADVAN6 all models run
slower and this is not really a solution of our problem.

We run NONMEM VI without the recent bug fixes in a "naked" fashion on the
server, and with "wings" on the PCs. Our compiler is Compaq Visual Fortran
(latest version).

We appreciate your thoughts on that.

__________________________________________
Joachim GREVEL, Ph.D.
MERCK SERONO International S.A.
Exploratory Medicine
1202 Geneva
Tel: +41.22.414.4751
Fax: +41.22.414.3059
Email: joachim.grevel_at_merckserono.net


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Received on Fri Dec 07 2007 - 07:56:48 EST