RE: [NMusers] hardware question

Thanks Diane,
  I know you don't care, but GO BUCKS tonight anyway

Mark Sale MD (OSU BS '81, MD '85)
Next Level Solutions, LLC
www.NextLevelSolns.com


> -------- Original Message --------
> Subject: RE: [NMusers] hardware question
> From: "Diane R Mould" <drmould_at_attglobal.net>
> Date: Mon, January 08, 2007 10:43 am
> To: "'Mark Sale - Next Level Solutions'" <mark_at_nextlevelsolns.com>
> Cc: <nmusers_at_globomaxnm.com>
>
> Hi Mark
>
> Yes, clients often want to be able to reproduce a contractor's results by
> re-running the final model on their own system and I would also say that the
> regulators do as well. For Nonmem V, therefore, having different compilers
> and processors is a valid concern. I think Peter Bonate had a poster at
> AAPS some years ago investigating differences in hardware and compilers.
>
> However for Nonmem VI, our experience thus far has been that it is not as
> sensitive to compilers and hardware. In fact it also appears to be less
> sensitive than Nonmem V was to the run termination status as well (so even
> if the runs terminate, parameter estimates are generally pretty good, as is
> the OBJ), which I think is consistent with what Tom Ludden presented when he
> gave a preview of Nonmem VI. So for your hardware, I would guess if Nonmem
> VI is the system you will be using for future consulting jobs, you should
> not have problems duplicating your results on other hardware.
>
> Good luck finding a buyer :-)
>
> Diane
>
> > -----Original Message-----
> > From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
> > On Behalf Of Mark Sale - Next Level Solutions
> > Sent: Monday, January 08, 2007 10:18 AM
> > Cc: nmusers_at_globomaxnm.com
> > Subject: [NMusers] hardware question
> >
> > For those of you who don't keep track of such things, Intel is, today,
> > releasing the desktop (non-gaming) quad core CPU. I'm thinking of
> > redoing my entire network, buying maybe 8 quad core machines for the GA
> > application, as well as parallel NONMEM. My question is, as a
> > consultant, my clients frequently want to re-run final models on their
> > hardware - and I assume that the regulators do as well. How much of a
> > problem will it be if I set up my system as 64 bit Vista (or XP) with
> > the Intel 64 bit compiler? There will be times when the 64 bit result
> > will be different than the 32 bit (as there are times when different
> > compiler setting, different compiler etc give different results). Is
> > anyone out there planning to move to 64 bit Intel? Will anyone be able
> > to rerun my results? It seems, as far as I can tell, the 64 bit system
> > is maybe 20-40% faster than a comparable 32 bit system. So, quad core,
> > 64 bit and NONMEM VI (which is faster than NONMEM V), should make a
> > noticable difference.
> >
> >
> > Thanks
> > (anyone out there want to buy 12 slightly used dual core computers?)
> >
> > Mark Sale MD
> > Next Level Solutions, LLC
> > www.NextLevelSolns.com
> >
> >

Received on Mon Jan 08 2007 - 13:12:22 EST