RE: [NMusers] problem with simulation run

Navin,

Below is an old posting from Bill Bachman that should help you with your
problem.

-Max

 

From: "Bachman, William" <bachmanw_at_globomax.com>

Subject: RE: Changing number of observations per indivdual record.

Date: Tue, 15 May 2001 08:15:36 -0400

 

David,

 

Yes, you are looking the wrong place. To change the no. of records per
individual you need to make the changes to the files in the main
directory (usually c:\nmv), delete the original subdirectories, and
re-compile using setup.bat to make the changes take effect. Complete
instructions below:

 

**********************************************************************

 

INSTRUCTIONS FOR CHANGING THE LIMIT ON THE NUMBER OF OBSERVATIONS PER
INDIVIDUAL RECORD

 

NONMEM, PREDPP and NMTRAN need to be recompiled for changes to NSIZES,
TSIZES and LSIZES files to take affect.

 

If NONMEM V was installed using the SETUP.BAT installation utility, here
is an easy way to make this change.

 

In the following, it is assumed that the NONMEM V directory is c:\nmv.

 

If not, use the appropriate drive and directory.

 

The steps are:

 

1. Change to c:\nmv and make the changes to NSIZES, TSIZES and LSIZES
(the parameter to changes is NO=50 to a larger number, e.g. 150)

 

C NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD

 

PARAMETER (NO=150)

 

2. Delete the previous versions of these files:

 

del nm\nsizes

 

del tr\tsizes

 

del tl\lsizes

 

3. Delete the previous object files from all subdirectories:

 

del *.obj /s

 

4. Delete the previous nonmem library file and NM-TRAN executable:

 

del nm\nonmem.lib

 

del tr\nmtran.exe

 

5. Determine the setup commands used previously to install NONMEM:

 

type setup.txt

 

6. Use SETUP.BAT to recompile all routines. (Use here the same arguments
that were used originally, if any.) SETUP.BAT will automatically skip
all other steps.

 

setup a c nmv df y

 

In the above, it is assumed that SETUP.BAT remains in the NONMEM V
directory where it was copied during installation. If not, it can be run
from diskette as it was originally:

 

a:\SETUP a c nmv df y

**********************************************************************

 

 

-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
On Behalf Of navin goyal
Sent: Wednesday, January 24, 2007 12:21 PM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] problem with simulation run

 

Hello everybody,
I am trying to run some simulation files in nonmem.
When I run the code, i get the output file with the error message as
follows

0TOT. NO. OF OBSERVATIONS IN INDIVIDUAL REC NO. 1 (IN INDIVIDUAL REC
ORDERING) EXCEEDS 200
 SEE INSTALLATION GUIDE
Stop - Program terminated.

Could someone help me with this. My senior told me that I need to change
some nonmem file settings for this code to run. there are about 500
observation time points for each patient.
Any help would be appreciated.
thanks
Navin

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Received on Wed Jan 24 2007 - 13:50:33 EST