[NMusers] Peculiar output file - no doubt I'm missing something obvious - help requested

Hi everyone,

In running a basic control stream, FO, on a relatively small .csv
dataset from a single dose trial, I get the following in my NONMEM
results file:

0MINIMIZATION SUCCESSFUL
 NO. OF FUNCTION EVALUATIONS USED: 2319
 NO. OF SIG. DIGITS IN FINAL EST.: 3.5
0PRED EXIT CODE = 1

0INDIVIDUAL NO. 51 ID=0.60000000E+01 (WITHIN-INDIVIDUAL) DATA REC
NO. 3
 THETA=

  3.38E+01 4.87E-01 4.30E-01 4.99E+01 9.73E+02

 OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA

 A ROOT OF THE CHARACTERISTIC EQUATION IS ZERO BECAUSE

 K*K32 IS MUCH SMALLER THAN (K+K23+K32)**2.

 PERHAPS K OR K32 IS VERY SMALL, OR K23 IS VERY LARGE.

0PROGRAM TERMINATED BY FNLETA
 MESSAGE ISSUED FROM TABLE STEP

As you can probably see, and as was confirmed when this was run within
PDx-POP as opposed to within NONMEM itself, while minimization was
'successful', there is a problem. As a result, no tables for xpose were
generated and termination occurred. The problem may be a bound on one
of the micro constants, but I'm not sure.

Has anyone run into this before, and if so, what did you do to
workaround it?
Steven Charnick, PhD
Senior Investigator
Merck Research Laboratories
WP75B-1305
PO Box 4
West Point PA 19486


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Received on Wed Jan 24 2007 - 15:18:48 EST