[NMusers] Peculiar output file - no doubt I'm missing something obvious - help requested

> Hi everyone,
>
> In running a basic control stream, FO, on a relatively small .csv
> dataset from a single dose trial, I get the following in my NONMEM
> results file:
>
> 0MINIMIZATION SUCCESSFUL
> NO. OF FUNCTION EVALUATIONS USED: 2319
> NO. OF SIG. DIGITS IN FINAL EST.: 3.5
> 0PRED EXIT CODE = 1
>
> 0INDIVIDUAL NO. 51 ID=0.60000000E+01 (WITHIN-INDIVIDUAL) DATA
> REC NO. 3
> THETA=
>
> 3.38E+01 4.87E-01 4.30E-01 4.99E+01 9.73E+02
>
> OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA
>
> A ROOT OF THE CHARACTERISTIC EQUATION IS ZERO BECAUSE
>
> K*K32 IS MUCH SMALLER THAN (K+K23+K32)**2.
>
> PERHAPS K OR K32 IS VERY SMALL, OR K23 IS VERY LARGE.
>
> 0PROGRAM TERMINATED BY FNLETA
> MESSAGE ISSUED FROM TABLE STEP
>
> As you can probably see, and as was confirmed when this was run within
> PDx-POP as opposed to within NONMEM itself, while minimization was
> 'successful', there is a problem. As a result, no tables for xpose
> were generated and termination occurred. The problem may be a bound
> on one of the micro constants, but I'm not sure.
>
> Has anyone run into this before, and if so, what did you do to
> workaround it?
> Steven Charnick, PhD
> Senior Investigator
> Merck Research Laboratories
> WP75B-1305
> PO Box 4
> West Point PA 19486
>

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Received on Wed Jan 24 2007 - 15:45:06 EST