RE: [NMusers] Minimum patients number...

Rule of thumb that I found in a guideline when I arrived at Glaxo
(Wellcome) at the time. I think it came from Elion Fuseau, at least
she was the author of the document.
minimum 20 samples per parameter (thetas, omegas and sigmas) - so, for 8
parameters (5 basic parameters, k,v,ka,k32,k23, 2 omegas, 1 sigma = your
160 samples)
minimum 10 patients per eta

if data at good, more if data are noisy
seems reasonably to me.
But, the usual rules to define pk models - 3 terminal half lifes.

I think Steve Dufful has some software as well.



Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com


> -------- Original Message --------
> Subject: [NMusers] Minimum patients number...
> From: Ahmed Hawwa <ahawwa1_at_yahoo.com>
> Date: Thu, January 25, 2007 6:22 pm
> To: nmusers_at_globomaxnm.com
>
> Dear All,
>
> Any idea about the minimum number of patients needed
> to produce significant results using NONMEM. What
> about the number of samples from each patient?
>
> Our experience indicates that a minimum of 40 patients
> with 4 samples from each patient is required to
> produce good results.
>
> Ay idea is too much appreciated..
>
> Yours,
> Ahawwa
>
>
>
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Received on Thu Jan 25 2007 - 20:31:24 EST