RE: [NMusers] Minimum patients number...

Hi all,

Thank you all indeed for the valuable commenets. I
have actually 19 patients only and I need to look into
the PK parameters of two metabolites.

Minimum 10 patients per eta would mean 50-60 patients.
I'm sure this number would give optimal results but as
a matter of fact I don't think I would be able to
reach it.

> I would suggest that you assess each case on its
> merits and determine the
> effectiveness of any proposed design using either
> simulation linked with
> estimation (which is tedious, slow, not optimal but
> often effective)

Regarding using simultation do you mean to put certain
values of thetas and then run a simulation and compare
results with the actual concentrations or did I miss
the point?

> or an
> information theoretic technique (such as optimal
> design).
> The optimal design software WinPOPT
> (www.winpopt.com), which is freely
> available, allows you to rapidly assess the
> effectiveness of various designs
> as well as optimize a design within your specific
> study constraints (e.g.
> clinic visit times etc).

I think one of my study constrains is clinic visit
times since patients taking our drug are actually
outpatients and we are able to collect one sample only
at each clinic visit. would this software be of any
help??

Looking to hear from you soon.

Regards,
ahawwa



 
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Received on Fri Jan 26 2007 - 20:10:03 EST