[NMusers] COMPUTING COVARIANCE OF PREDICTION ERRORS IN NONMEM

From: NIYI ADEDOKUN <niyiadedokun_at_hotmail.com>
Date: Mon, 09 Jul 2007 22:10:29 +0000

Dear NMUsers,
Sometimes, it is desirable to compute an estimate of  the covariance of 2 prediction errors  in the same individual in order to estimate the variance of the sum of prediction errors in that  individual.


This estimate has been suggested by Vozeh et al. (1990) to be in the form:


ole0.bmp

where where covN(PEi,PEi’) is the covariance of the prediction errors i and i’ while E is the expectation  of the enclosed expression; g and h are partial derivatives of the vector of PK parameters with respect to the ç and å respectively, m is the number of etas in the model etc.)


My question is: how can this be coded/outputted from a NONMEM run.

Thanks for your help.
Jo

Received on Mon Jul 09 2007 - 18:10:29 EDT

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