RE: [NMusers] Simultaneous PK and Cell Life Span PD modeling

Hi,

Then let me ask the readers about their experience with estimating ETAs
on every single structural model parameter. I have seen many examples of
NM control streams, where in addition to a complex structural model also
several variability terms are implemented. In my limited experience, it
is rather unlikely to be able to get meaningful estimates of all these
parameters based on measurements of a single compartment in the model.

It would be interesting to hear other people's comments.

Toufigh

-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
On Behalf Of Wei-Jian Pan
Sent: Wednesday, July 18, 2007 10:52 AM
To: Mark Sale - Next Level Solutions
Cc: nmusers_at_globomaxnm.com
Subject: RE: [NMusers] Simultaneous PK and Cell Life Span PD modeling

Mark:

Thanks for your suggestions! I have removed "DEFOBS"
from CMT6, and it is now running.

Toufigh:

Yes, I do have dense PK and PD data for this modeling
exercise. I presented the simultaneous PK/PD modeling
results at last month's AAPS NBC as a poster. I am now
attempting to use the cell life span model to see if
there any improvements in model fitting. Note that
this is an mAb which reduces the NK cell count in the
peripheral blood.

Thanks!

Wei-jian



 
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Received on Thu Jul 19 2007 - 12:22:19 EDT