Re: [NMusers] Metrum Institute releases NMQual 6.2.0

Tom,

Ludden, Thomas (MYD) wrote:
> Tim,
> Can you describe the "fix" for the boundary condition "issue". Comments

We've implemented a suggestion from Rik Schoemaker. In CN.for, CN1.for,
and DECN1.for, "DATA INCR/1E-02/" is replaced with "DATA INCR/0/".

> I have received about this feature that Stuart Beal introduced into
> NONMEM version VI have been both positive and negative. In many cases
> this feature can prevent an attempt to execute the covariance step with
> the loss of associated computing time when success is very unlikely.
> There are ways to selectively inactivate this feature. Does NMQual allow
> selective inactivation?

NMQual does allow selective inactivation. Stuart Beal's boundary
checking is inactivated by default if changes.nm6.bugs.xml is cited
(uncommented) in the configuration file (e.g., config.template.xml). To
preserve boundary checking, find the comment "Remove boundary checking"
in changes.nm6.bugs.xml, and then delete the next 42 lines of text
(lines 284 to 325).

We are aware that the boundary checking is not a bug, and it was perhaps
  awkward of me to describe the change as a 'fix'. My apologies.
"Selective inactivation" is much better; thanks for pointing it out.

Regards,

Tim.

> Thanks
> Tom
> -----Original Message-----
> From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
> On Behalf Of Tim Bergsma
> Sent: Thursday, June 14, 2007 1:01 PM
> To: nmusers_at_globomaxnm.com
> Subject: [NMusers] Metrum Institute releases NMQual 6.2.0
>
> Metrum Institute is pleased to announce the release of NMQual version
> 6.2.0. Support for PDx-Pop has been introduced. WFN '570' sizes have
> been adopted as an option for NONMEM6 installations. A fix has been
> implemented for the 'boundary condition' issue in NONMEM6. Other
> changes are summarized at the 'changes' link below. NMQual is a system
> for creating NONMEM installations, featuring scripted bug fixes and
> self-documenting output.
>
> Regards,
>
> Tim Bergsma, PhD
> Metrum Research Group, LLC
>
> homepage: http://metruminstitute.org/downloads/nmqual/
> download: http://metruminstitute.org/downloads/nmqual/nmqual-6.2.0.zip
> changes : http://metruminstitute.org/downloads/nmqual/#updates
>
>
>
>
>
>
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Received on Thu Jun 14 2007 - 15:25:18 EDT