Re: [NMusers] Coding infusions

Hi Batul,
I have never modeled patients with different infusion rate. However I found
out this example on the ACCP website. Maybe this will be of some help to
you. I guess you need to calculate the Dose (amount=rate *time of Infu) and
enter it
http://accp1.org/pharmacometrics/cssolutionnm.htm#cs3 (Case Study # 3)
the example also mentions that ----------Infusion rate, given the infusion
rate NONMEM calculates the duration of
infusion.
So it might be something like..
ID TIME Conc AMT RATE MDV
1 0 40 20 1
1 0.5 -- 0 0 0

2 0 200 10 1
2 0.5 -- 0 0 0


3 0 400 20 1
3 0.5

The example from ACCP is as follows

 C Intravenous infusion-One compartment-Single dose Study
 C No.of Subjects=20, AMT=Dose100mg for 6 hr =16.7mg/hr


 C Time in hrs, CONC=Plasma Concentration in ng/ml,Clearance=L/hr,Volume=L
CID TIME CONC AMT RATE MDV

 1 0 0 100 16.7 1

 1 0.5 94.324 0 0 0

 1 1 202.81 0 0 0

 1 3 428.36 0 0 0

 1 5 678.33 0 0 0

 1 6 590.98 0 0 0

 1 8 450.33 0 0 0

 1 12 233.45 0 0 0

 1 15 156.33 0 0 0

 1 18 86.048 0 0 0

 1 24 30.676 0 0 0

 1 30 11.06 0 0 0

 2 0 0 100 16.7 1

 2 0.5 72.945 0 0 0

 2 1 154.01 0 0 0

 2 3 444.39 0 0 0

 2 5 622.84 0 0 0



Good Luck


Navin


On 6/16/07, Batul Parta <batulparta_at_yahoo.com> wrote:
>
> Dear Colleagues,
>
> I am trying to model 3 subjects with different infusions: subj. 1: 20 mg/h
> for 2 hrs, subj. 2: 20 mg/h for 10 hours, and subj. 3: 20 mg/h for 20 hours.
> Could someone help me do this by filling the table below:
>
> ID TIME AMT DUR RATE
> 1 0
> 2 0
> 3 0
>
> Thank you in advance,
>
> BP
>
> ------------------------------
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--
--Navin

Received on Sat Jun 16 2007 - 17:19:10 EDT