[NMusers] Modeling enantiomeric and racemic concentrations simultaneously

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10 Dear all,
I have conducted a pharmacokinetic study in rat and I have a question about=
 how to model enantiomeric and racemic concentrations simultaneously. =

The study design was as follows:
Sparse data (2 - 3 plasma samples, n=10 rats) was collected for the two =
enantiomers, and rich data for the racemate (10-15 plasma samples, n=4 ra=
ts) following oral administration.
I would like to build an individual model for each enantiomer and use the r=
acemic data to stabilize the sparse data I have on the enantiomers. Do you =
have any suggestions how this could be done and how such a control-file sho=
uld be written?

Kind regards,
Rasmus Jansson
_____________________________________________ Rasmus Jansson Unit for Pha=
rmacokinetics and Drug Metabolism Göteborg University P.O.Box 431, SE-4=
05 30 Göteborg Sweden Phone: +46(0)31 786 3240 Fax: +46 (0)31 786 3284=


Received on Mon Jun 18 2007 - 09:26:14 EDT