RE: [NMusers] processing simultaneous infusion

Basically, if you are using PREDPP models (but not $PRED models), NONMEM
dosing is very simple and uses the principal of superposition. So doses are
additive and you just code for the first infusion giving its time, rate and
amt, then the second dose by time, rate and amt. So your first way is
correct (no starting and stopping is necessary).


-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On
Behalf Of m.j.e.brill_at_umail.leidenuniv.nl
Sent: Monday, June 25, 2007 11:39 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] processing simultaneous infusion

Dear all,

I am student and just started working with NONMEM. At the moment I'm still
preparing my datasheet, in which I have one particular issue that I do not
know
how to solve:

During surgery the patients from my dataset received an infusion with a
certain
rate, but sometimes an extra infusion (for only 5 to 10 seconds,
administered
at a different site) is given on top of the first infusion. How can I best
describe/present these events in my datasheet?

Can I just simply add it to the infusion AMT, as I have done in the sheet
below?
Here, I presume that the first infusion still continues for one hour.

TIME (min)AMT (mg)RATE (mg/min) TYPED EVENT
0.00 200 3.33 First infusion starts
10.00 . . Some event not of importance to AMT or RATE
15.00 40 240 Extra infusion of 40 mg in 10 sec.
40.00 . . Some event not of importance to AMT or RATE
60.00 . . Stopping the (first) infusion

Or should I 'stop' the first infusion after 15 minutes, add the amount of
the
first infusion to the extra infused amount during the period of extra
infusion
(creating an extra TYPED EVENT), and then again start the first infusion at
the
moment the extra infusion stops (at 15.17 minutes)?

TIME (min) AMT (mg) RATE (mg/min) TYPED EVENT
0.00 50 3.33 First infusion starts
10.00 . . Some event not of importance to AMT or
RATE
15.00 0.56+40 242.85 Extra infusion of 40 mg in 10 sec or 1/6
min.
15.17 149.44 3.33 Starting first infusion again.
40.00 . . Some event not of importance to AMT or
RATE
60.00 . . Stopping the (first) infusion

Or is there another way of processing these simultaneous infusions the right
way? Has anybody worked with this way of infusing, who might give me a few
hints on this problem?

Thank you in advance and best regards,
Margreke Brill


Received on Mon Jun 25 2007 - 13:23:53 EDT