[NMusers] Additive model for IOV and IIV within a logit-transform

Dear NMusers,
In a paper by Kerbusch, Wählby, Milligan, & Karlsson (BJCP 56 (6), =
639-652) the authors state that: "The bioavailability (F) depended on =
the formulation (immediate = IR or extended = CR), the dose, and =
CYP2D6 genotype. Interindividual variation for FIR and FCR, and =
interoccasion variability for FIR and FCR were described using additive =
models within a logit-transform" and reported

VARIABILITY ESTIMATE (CV)
IIV F,IR 67% (20%)
IIV F,CR 67% (20%)
IOV F 37% (13%)

Could a kind NMuser please provide the additive model for IOV and IIV =
within a logit-transform. MORE importantly, please elucidate the formula =
for computing the variability estimate of IIV and IOV in F. The table =
footer states "F: bioavailability centred at median dose". Does this =
mean that the reported variability estimate is only relevant at the =
computed F value for the median dose?

Thanking you in advance...MNS



Received on Fri Jun 29 2007 - 19:11:50 EDT