[NMusers] AUC and segmented post treatment exposure

Dear all,

I am working with a population model of 100 patients sparsely sampled for 6=
0 days. It is a 2-compartment model with first order absorption and repeat=
ed oral administration for 3 days. I have some difficulties in finding a co=
de for estimating AUC for these patients so if anyone could help me that wo=
uld save me a lot of time.

How do I code for AUC in repeated oral dosing for a 2-compartment model?

Is it possible to code for AUC segments (e.g. 0-20 days and/or 20-40 days a=
fter administration)?

Thanks
/Joel Tarning


_____________________________________________
Joel Tärning, MSc, PhD-student

Göteborg University
Department of Pharmacology
P.O. Box 431
405 30 Göteborg

Phone:   +46 (0) 31 773 3240
Cellular: +46 (0) 708 514849
Fax:       +46 (0) 31 773 3284
e-mail:   Joel.Tarning_at_pharm.gu.se (mailto:Joel.Tarning_at_pharm.gu.se)


Received on Tue Mar 27 2007 - 10:09:43 EDT