Re: [NMusers] NONMEM ODE solver

Dear Dr Sale,

ADAPT (including Adapt II (Rel. 4), Adapt V, and S-Adapt) uses the LSODA (Livermore Solver for
Ordinary Differential equations with Automatic method switching for stiff and nonstiff problems).

According to the Adapt user guide:
"The ability of LSODA to detect stiffness and switch between Adam's and Gear's methods,
together with its capability to control the step size and order of the selected method, makes
this program [ADAPT] the most robust we know of for this application."

I have not yet run a head to head comparison of the stability of the ODE solver in Adapt
and NONMEM on the same project myself. However, some of my colleagues told me that
they found the LSODA in Adapt very robust. I would be happy, if someone could share
his/her opinion on the robustness of ODE solvers e.g. implemented in PKPD programs.

Best regards
Juergen


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Juergen Bulitta, PhD, Post-doctoral Fellow
Pharmacometrics, University at Buffalo, NY, USA
Phone: +1 716 645 2855 ext. 281, j_at_bulitta.com
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Received on Sun May 27 2007 - 18:19:13 EDT