RE: [NMusers] NONMEM ODE solver

Hi Juergen
 
The LSODA solver is also implemented in the odesolve package in R and =
used together with nlme for mixed-effects modeling in nlmeODE.
 
I don't think you will find many PKPD programs with more well-tuned ODE =
solvers for mixed-effects modeling compared to NONMEM. You might also =
want to take a look at programs in other scientific areas besides PKPD =
since I've heard there has been quite a bit of improvements in the ODE =
solver field especially tuned for estimation problems.
 
Best
 
Chris

________________________________

Fra: owner-nmusers_at_globomaxnm.com på vegne af Jurgen Bulitta
Sendt: sø 27-05-2007 18:19
Til: nmusers_at_globomaxnm.com
Emne: Re: [NMusers] NONMEM ODE solver



Dear Dr Sale,

ADAPT (including Adapt II (Rel. 4), Adapt V, and S-Adapt) uses the LSODA =
(Livermore Solver for
Ordinary Differential equations with Automatic method switching for =
stiff and nonstiff problems).

According to the Adapt user guide:
"The ability of LSODA to detect stiffness and switch between Adam's and =
Gear's methods,
together with its capability to control the step size and order of the =
selected method, makes
this program [ADAPT] the most robust we know of for this application."

I have not yet run a head to head comparison of the stability of the ODE =
solver in Adapt
and NONMEM on the same project myself. However, some of my colleagues =
told me that
they found the LSODA in Adapt very robust. I would be happy, if someone =
could share
his/her opinion on the robustness of ODE solvers e.g. implemented in =
PKPD programs.

Best regards
Juergen


-----------------------------------------------
Juergen Bulitta, PhD, Post-doctoral Fellow
Pharmacometrics, University at Buffalo, NY, USA
Phone: +1 716 645 2855 ext. 281, j_at_bulitta.com
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Received on Mon May 28 2007 - 08:34:16 EDT