[NMusers] trough time same as dosing time

Dear NMusers,

A single-dose of drug was given to healthy volunteers and a PK model
incorporating Michaelis-Menten distribution nicely captured the
concentration-time profile.

The same drug was given to healthy volunteers once daily for consecutive
7 days. The same PK model developed on the single-dose data were fitted
to multiple-dose data, however, nonmem minimization was terminated. In
the dataset, the time of trough sample is coded exactly same as the time
for next dose according to the study protocol, for example, the time for
trough on day 1 and time for dosing on day 2 is 24 hr. Actually, it will
never be the case in the real clinical setting. My gut feeling is coding
in this way may cause numerical errors. Can someone shed light on it so
that I can request the clock time for dosing and sampling?

Thank you very much! Ying

--
Ying HONG, PhD
Department of Pharmaceutical Sciences
University at Buffalo, SUNY
C237 Cooke Hall, Buffalo, NY 14260

Tel: 716 645 2828 ext 275
Fax: 716 645 3693
E-mail: yhong6_at_buffalo.edu


Received on Tue May 29 2007 - 01:03:11 EDT