[NMusers] PK/PD analyses in toxicology for tox prediction in humans

Dear all,

in drug development, is anybody aware of examples of population PK/PD
analyses in toxicology and how the resulting PKPD relation might be used
for prediction of toxic effects in humans prior to first-in-man studies?

Thanks and best regards
Nele
_________________________
Dr. Nele Plock
Bayer Schering Pharma AG
Drug Metabolism & Pharmacokinetics
Development Pharmacokinetics
Scientific Expert Development Pharmacokinetics
D- 13342 Berlin

Phone : +49-30-468 15146
Fax: +49-30-468 95146
nele.plock_at_bayerhealthcare.com
http://www.bayerscheringpharma.de

Vorstand: Arthur J. Higgins, Vorsitzender | Werner Baumann, Andreas Busch, =

Ulrich Köstlin, Kemal Malik, Gunnar Riemann
Vorsitzender des Aufsichtsrats: Werner Wenning
Sitz der Gesellschaft: Berlin | Eintragung: Amtsgericht Charlottenburg 93
HRB 283
Received on Mon Nov 05 2007 - 03:53:38 EST