RE: [NMusers] Steady_state Dataset for NM

Dear Jian,
 
The ADDL data item speaks of doses in the future, therefore you need to =
include dosing records at day 1 (see addition in example below). In case =
that you are not absolutely certain that plasma concentrations would =
have reached steady state by day 5 I think that this is a better =
alternative than to use the SS option.
 
Kind regards,
Martin Bergstrand, MSc, PhD student
-----------------------------------------------
Division of Pharmacokinetics and Drug Therapy
Department of Pharmaceutical Biosciences
Uppsala University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
martin.bergstrand_at_farmbio.uu.se
-----------------------------------------------
Work: +46 18 471 4639
Mobile: +46 709 994 396
Fax: +46 18 471 4003

 -----Original Message-----
From: owner-nmusers_at_globomaxnm.com =
[mailto:owner-nmusers_at_globomaxnm.com]On Behalf Of Jian Xu
Sent: 6 november 2007 00:45
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Steady_state Dataset for NM



Dear NM users,

I have a question about creating a steady-state dataset for NM.
Study design:
Multiple dose regimen (10 days study)
(everyday, two doses were given, one is 100 in the morning 8AM, and the =
other one is 150 in the evening 8PM)
multiple samples (from 8AM to 8PM) were taken on day 5 (assuming at =
steady-state).

I made a dataset as following, and it seems not working. Would you point =
out what I missed? Should I use SS option?
Thanks a lot.

Jian
ID TIME DAY DV AMT ADDL II EVID
1 0 1 . 100 3 24 1 *
1 12 1 . 150 3 24 1 *
1 0 5 . 100 5 24 1
1 0 5 2 . . . 0
1 0.5 5 5 . . . 0
.
.
1 8 5 23 . . . 0
1 10 5 26 . . . 0
1 12 5 29 . . . 0
1 12 5 . 150 5 24 1
2 0 1 . 100 3 24 1 *
2 12 1 . 150 3 24 1 *
2 0 5 . 100 5 24 1
2 0 5 2 . . . 0
2 0.5 5 7 . . . 0
.
.
2 8 5 37 . . . 0
2 10 5 42 . . . 0
2 12 5 47 . . . 0
2 12 5 . 150 5 24 1
3 0 1 . 100 3 24 1 *
3 12 1 . 150 3 24 1 *
3 0 5 . 100 5 24 1
.
.



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Received on Tue Nov 06 2007 - 04:34:11 EST