Re: [NMusers] Steady_state Dataset for NM

Hi, Martin, and Andreas,

Thanks for the quick response. Actually, I was not sure about how to use SS option. But I guess starting from day 1 will be the best choice.

Thank you again, and have a nice day,

Jian

----- Original Message ----
From: "Bergstrand, Martin" <Martin.Bergstrand_at_astrazeneca.com>
To: Jian Xu <alanub_at_yahoo.com>; nmusers_at_globomaxnm.com
Sent: Tuesday, November 6, 2007 9:02:08 AM
Subject: RE: [NMusers] Steady_state Dataset for NM



 


DIV {
MARGIN:0px;}



Dear
Jian,

 

A colleague pointed out that there is another
potential problem with the presented dataset. DAY is not a recognised variable
in NONMEM. Therefore you need to add either a DATE data item (DATE, DAT1, DAT2
or DAT3) or change the TIME records so that you have continuous time in
hours (se example for ID=1 below).

 

I hope
this solves your problem.

 

Kind
regards,

Martin


  -----Original Message-----
From: owner-nmusers_at_globomaxnm.com
  [mailto:owner-nmusers_at_globomaxnm.com]On Behalf Of Bergstrand,
  Martin
Sent: 6 november 2007 10:34
To: Jian Xu;
  nmusers_at_globomaxnm.com
Subject: RE: [NMusers] Steady_state Dataset
  for NM



  Dear
  Jian,

   

  The
  ADDL data item speaks of doses in the future, therefore you need to
  include dosing records at day 1 (see addition in example below). In case
  that you are not absolutely certain that plasma concentrations would have
  reached steady state by day 5 I think that this is a better alternative than
  to use the SS option.

   

  Kind
  regards,

  
  Martin Bergstrand, MSc, PhD student
  
-----------------------------------------------
Division of Pharmacokinetics and Drug Therapy
  
Department of Pharmaceutical
  Biosciences
Uppsala
  University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
martin.bergstrand_at_farmbio.uu.se
-----------------------------------------------
Work: +46 18 471 4639
Mobile: +46 709 994 396
Fax: +46 18 471 4003
  



   -----Original
  Message-----
From: owner-nmusers_at_globomaxnm.com
  [mailto:owner-nmusers_at_globomaxnm.com]On Behalf Of Jian
  Xu
Sent: 6 november 2007 00:45
To:
  nmusers_at_globomaxnm.com
Subject: [NMusers] Steady_state Dataset for
  NM



  
    
    Dear NM users,

I have a question about creating a steady-state
    dataset for NM.
Study design:
Multiple dose regimen (10 days
    study)
(everyday, two doses were given, one is 100 in the morning 8AM,
    and the other one is 150 in the evening 8PM)
multiple samples (from 8AM
    to 8PM) were taken on day 5 (assuming at steady-state).

I made a
    dataset as following, and it seems not working. Would you point out what I
    missed? Should I use SS option?
Thanks a
    lot.

Jian
ID TIME
    DAY DV AMT
    ADDL II EVID
1 0 1 .
    100 3 24
    1
    *
1 12 1
    . 150 3 24
    1
    *
1 96
    5 . 100
    5 24 1
1 96
    5 2 .
    . . 0
1 96.5 5
    5 . .
    . 0
.
.
1 104
    5 23 .
    . . 0
1 106
    5 26 .
    . . 0
1 108
    5 29 .
    . . 0
1 108
    5 . 150
    5 24 1
2
    0 1 .
    100 3 24
    1
    *
2
    12 1
    . 150 3 24
    1
    *
2 0
    5 . 100
    5 24 1
2
    0 5 2
    . . .
    0
2 0.5 5
    7 . .
    . 0
.
.
2 8
    5 37 .
    . . 0
2
    10 5 42
    . . .
    0
2 12 5
    47 . .
    . 0
2 12
    5 . 150
    5 24 1
3
    0 1 .
    100 3 24
    1
    *
3
    12 1
    . 150 3 24
    1
    *
3 0
    5 . 100
    5 24
    1
.
.




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Received on Tue Nov 06 2007 - 10:24:04 EST