[NMusers] CHANGING THE SIZE OF BUFFER 1?

Dear nmusers

I'm currently working on a pharmacokinteic population analysis of a rather large data set in NONMEM version VI for my master degree.

My data set consist currently of 9 patients that I follow over a time period of 2-4 months. This causes my data set to exceed 500 data records for some of the individuals.

When I try to run it in NONMEM version VI, I get the following error message

TOT NO. OF DATA RECS IN BUFFER 1 IS LESS THAN
NO. OF DATA RECS IN INDIVIDUAL REC NO. 3 (IN INDIVIDUAL REC ORDERING)
SEE INSTALLATION GUIDE

I've found out that I need to increase the size of Buffer 1 from the default of 400, but I do not understand how to do so.

The "SIZES" file in the folder "nmvi" apparently needs to be changed, but it says that I need to "RECOMPILE NONMEM IF ANY CONSTANT IN THIS SECTION IS CHANGED"

I would be very greatful if anyone could explain to me in detail how this is done.

With kind regards
Truc Thanh van Le Master student
Institute of Pharmacy
University of Oslo
Norway