RE: [NMusers] CHANGING THE SIZE OF BUFFER 1?-->CHANGING THE LIMIT ON THE NUMBER OF OBSERVATIONS PER INDIVIDUAL RECORD for NONMEM VI

***********************************************************************

INSTRUCTIONS FOR CHANGING THE LIMIT ON THE NUMBER OF OBSERVATIONS PER
INDIVIDUAL RECORD

NONMEM, PREDPP and NMTRAN need to be recompiled for changes to SIZES
files to take affect.

If NONMEM VI was installed using the CDSETUP6.BAT installation utility,

here is an easy way to make this change.

In the following, it is assumed that the NONMEM VI directory is c:\nmvi.

If not, use the appropriate drive and directory.

The steps are:

1. Change to c:\nmv and make the changes to SIZES (the parameter to
changes is NO=250 to a larger number, e.g. 500)

C NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD

PARAMETER (NO=500)

2. Delete the previous object files from all subdirectories:

del *.obj /s

3. Delete the previous nonmem library file and NM-TRAN executable:

del nm\nonmem.lib

del tr\nmtran.exe

4. Determine the setup commands used previously to install NONMEM:

type setup.txt

5. Use CDSETUP6.BAT to recompile all routines. (Use here the same
arguments that were used originally, if any.) SETUP.BAT will
automatically skip all other steps.

cdsetup6 a c nmvi df y


________________________________

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
On Behalf Of Truc Thanh van Le
Sent: Wednesday, October 24, 2007 8:06 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] CHANGING THE SIZE OF BUFFER 1?


Dear nmusers

I'm currently working on a pharmacokinteic population analysis of a
rather large data set in NONMEM version VI for my master degree.

My data set consist currently of 9 patients that I follow over a time
period of 2-4 months. This causes my data set to exceed 500 data records
for some of the individuals.

When I try to run it in NONMEM version VI, I get the following error
message

TOT NO. OF DATA RECS IN BUFFER 1 IS LESS THAN
NO. OF DATA RECS IN INDIVIDUAL REC NO. 3 (IN INDIVIDUAL REC ORDERING)
SEE INSTALLATION GUIDE

I've found out that I need to increase the size of Buffer 1 from the
default of 400, but I do not understand how to do so.

The "SIZES" file in the folder "nmvi" apparently needs to be changed,
but it says that I need to "RECOMPILE NONMEM IF ANY CONSTANT IN THIS
SECTION IS CHANGED"

I would be very greatful if anyone could explain to me in detail how
this is done.

With kind regards
Truc Thanh van Le Master student
Institute of Pharmacy
University of Oslo
Norway


 



___________________________________________________________________________=
__________________________________
ICON plc made the following annotations.
---------------------------------------------------------------------------=
---
This e-mail transmission may contain confidential or legally privileged =
information that is intended only for the individual or
entity named in the e-mail address. If you are not the intended recipient, =
you are hereby notified that any disclosure, copying,
distribution, or reliance upon the contents of this e-mail is strictly =
prohibited. If you have received this e-mail transmission
in error, please reply to the sender, so that ICON plc can arrange for =
proper delivery, and then please delete the message.
Thank You.
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835
___________________________________________________________________________=
___________________________________




Received on Wed Oct 24 2007 - 09:09:00 EDT