Re: [NMusers] Reporting Modeling Results

Hi John,
The code seems to be good, and the results, in my opinion, should not
depend on scaling. One idea: if you started both sets of problems (with
and without scaling) from the same initial conditions (while the
solutions differ by factor 5 or so), nonmem could have difficulties
finding the correct minimum when started far from optimum. If your
initial conditions were coming from 10.4 kg-normalized solution, then it
could explain wider CI for the non-normalized problem: some of those
runs did not converged or converged to a local minima. If this is true,
you may want to repeat the non-normalized set with the initial
conditions closer to the solution (if you choose to use non-normalized
problem as the final model).
Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566




John Mondick wrote:
>
>
> $PK
>
> TVCL = THETA(1)*(WT/10.4)**0.75
> BETA = THETA(5)
> TCL = THETA(6)
> FCL = 1-BETA*EXP(-(AGE-1)*0.693/TCL)
> TVCL2 = TVCL*FCL
> CL = TVCL2*EXP(ETA(1))
>
> TVV1 = THETA(2)*(WT/10.4)
> V1 = TVV1*EXP(ETA(2))
>
> TVV2 = THETA(3)*(WT/10.4)
> V2 = TVV2*EXP(ETA(3))
>
> TVQ = THETA(4)*(WT/10.4)**0.75
> Q = TVQ
>
Received on Thu Oct 25 2007 - 17:30:11 EDT