Re: [NMusers] Modeling a concentration curve with secondary peaks?

Xiaoli,

Try a dual absorption compartment model e.g. with ADVAN6. Here is a 1comp with 2 absorption comps:

$MODEL

 COMP = (ABS1)
 COMP = (ABS2)
 COMP = (CENTRAL)

.......

$DES

 DADT(1) = -K13*A(1)
 DADT(2) = -K23*A(2)
 DADT(3) = K13*A(1) + K23*A(2) - KE*A(3)

Give a full dose to each absorption compartment, estimate F1 and code F2 as:

 F2 = 1 - F1

You can then estimate lag/abs rate constants/transit model parameters for each absorption comp to catch the doubles.

Hope this helps,

Joe


At 13:55 26/10/2007, Hou, Xiaoli Shirley (Shirley) wrote:
>I need help for modeling a concentration curve with secondary peaks. What models could I use? I tried two compartment models, but it couldn’t capture the secondary peaks. Suggestions or recommendations are highly appreciated.
>
>Thanks.
>
>Dr. Xiaoli Shirley Hou
>Senior Biometrician, Biometrics Research
>Merck Research Labs WP53-120
>West Point PA 19486
>Phone (215) 652-7498 (first week of each month)
>Phone (540) 381-9599 (rest of time)
>Fax (215) 993-1835
>
>
>
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Received on Fri Oct 26 2007 - 10:14:26 EDT