Re: [NMusers] Modeling a concentration curve with secondary peaks?

With a linear model such as this one, you can also use ADVAN7 (or
ADVAN5). These are likely to give more stable numerical results than
can be obtained by integrating differential equations.

Omit the $DES block. The names given to the rate constants define the
connections between the compartments,
e.g.,

$PK
K13= ...
K23=...
K30=....


On Fri, 26 Oct 2007 15:14:26 +0100, "Joseph Standing"
<Joseph.Standing_at_pharmacy.ac.uk> said:
> Xiaoli,
>
> Try a dual absorption compartment model e.g. with ADVAN6. Here is a
> 1comp with 2 absorption comps:
>
> $MODEL
>
> COMP = (ABS1)
> COMP = (ABS2)
> COMP = (CENTRAL)
>
> .......
>
> $DES
>
> DADT(1) = -K13*A(1)
> DADT(2) = -K23*A(2)
> DADT(3) = K13*A(1) + K23*A(2) - KE*A(3)
>
> Give a full dose to each absorption compartment, estimate F1 and code F2
> as:
>
> F2 = 1 - F1
>
> You can then estimate lag/abs rate constants/transit model parameters for
> each absorption comp to catch the doubles.
>
> Hope this helps,
>
> Joe
>
>
> At 13:55 26/10/2007, Hou, Xiaoli Shirley (Shirley) wrote:
> >I need help for modeling a concentration curve with secondary peaks. Wha=
t models could I use? I tried two compartment models, but it couldn’t cap=
ture the secondary peaks. Suggestions or recommendations are highly appreci=
ated.
> >
> >Thanks.
> >
> >Dr. Xiaoli Shirley Hou
> >Senior Biometrician, Biometrics Research
> >Merck Research Labs WP53-120
> >West Point PA 19486
> >Phone (215) 652-7498 (first week of each month)
> >Phone (540) 381-9599 (rest of time)
> >Fax (215) 993-1835
> >
> >
> >
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--
  Alison Boeckmann
  alisonboeckmann_at_fastmail.fm

Received on Fri Oct 26 2007 - 10:30:16 EDT