[NMusers] Absorption

Thanks all for replying.

Murad,

I did try to model the effect of dose on bioavailability. I assumed
that the lower doses have a bioavailability of 1 and tried calculating
the bioavailability of higher doses relative to the lower doses. I
also added this effect on absorption rate constant. But the model
predictability at higher doses did not improve much.

I haven't tried an effect of dose as a covariate on volume of
distribution or absorption rate constant, i will try that out.

Stephen,

I tried using saturable absorption as an nonlinear absorption model,
Vmax*A(gut)/Km+A(gut) so at higher doses this becomes zero order and
at lower doses this becomes Vmax/Km *A(gut). This did not help me
much. I was still over predicting the concentrations leading to Cmax
by three-6 folds in higher dose groups.

Thanks
Adithya
Received on Mon Sep 03 2007 - 17:41:57 EDT