RE: [NMusers] hlep

I am not an expert in NO0NMEM but may be you need to request the posthoc IN THE $EST .

Best;

Serge Guzy

 

________________________________

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of yyzjyhs
Sent: Tuesday, April 01, 2008 6:28 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] hlep
Importance: High

 

  Name YanYun
Title range for CL is zero,scatterplot omitted
Organization College of Veterinary medicine,South China
              Agriculture University
E-mail Address yyzjyhs_at_126.com
Phone Number 13560250188
City GuangZhou
State GuangDong Province
Postal Code 510642
Country China
Nature of Problem

Dear All,
  Thanks for your help.
  I am a novice in using NONMEM.
  I am working on a PPK model.My control is:
$PROB THEOPHYLLINE POPULATION DATA
$INPUT ID DOSE=AMT TIME CP=DV WT SEX AGE AST ALT ALP TP CREA ALB GGT TBIL DBIL
$DATA YUANCHI
$SUBROUTINES ADVAN3 TRANS4

$PK
   CL=THETA(1)+ETA(1)
   V1=THETA(2)+ETA(2)
   Q=THETA(3)+ETA(3)
   V2=THETA(4)+ETA(4)
   K=CL/V1
   K12=Q/V1
   K21=Q/V2
   SC=V1
    
$THETA (0,1,100) (0,1,100) (0,3,100) (0,5,100)
$OMEGA .04 .04 1 1
$ERROR
   Y=F+EPS(1)
$SIGMA .1
$EST MAXEVAL=9999 PRINT=50
$COV
$SCAT CL VS (WT SEX AGE AST ALT ALP TP CREA ALB GGT TBIL DBIL)
$SCAT (CP PRED) VS TIME
$SCAT CP VS PRED UNIT
    it return "range for CL is zero,scatterplot omitted",and I try "CL=THETA(1)*EXP(ETA(1))" "CL=THETA(1)*(1+ETA(1)) ,too.It still show "orange for CL is zero,scatterplot omitted. what should I do?
  Thanks,
  
  YanYun

 

 

 





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