[NMusers] NM VI and NMV gave different results

Dear all,

I did a Pop PK a year ago in NM V, and got a stable model and reasonable estimation. Recently, I tried to rerun the same code in NM VI (with latest patches from Metrum) . The results are huge different. Some p-values for Eta from NM VI are even significant. I really want to know what the real difference is between NM VI and NM V. I appreciate any help or reference.

Thanks in advance.

Jian

Below is the control stream for your consideration:

$PROB 2CM

$DATA DATA.CSV IGNORE=#

$INPUT ID AMT TIME CON=DV MDV FST

$SUBROUTINES ADVAN4 TRANS4

$PK

V2=THETA(1)*EXP(ETA(1)) ; VOLUME OF CENTRAL
V3=THETA(2)*EXP(ETA(2)) ; VOLUME OF PERIPHERAL
CL=THETA(3)*EXP(THETA(7)*ETA(1)) ; CLEARANCE
Q =THETA(4)*EXP(ETA(3)) ; DISTRIBUTION CLEARANCE
IF (FST.EQ.1) THEN
KA=THETA(5)*EXP(ETA(4)) ; ABSORPTION RATE CONSTANT FOR FASTED
ELSE
KA=THETA(6)*EXP(ETA(5)) ; ABSORPTION RATE CONSTANT FOR FED
END IF

S2=V2

$ERROR

Y=F*(1+EPS(1))

$THETA
(0,150) ;V2_F
(0,200) ;V3_F
(0,6) ;CL_F
(0,50) ;Q_F
(0,0.5) ;KA
(0,0.2) ;KA
(0,1) ;CL_V Correlation

$OMEGA
0.01 0.01 0.01 0.01 0.01
$SIGMA
0.04

$ESTIMATION SIG=3 MAX=5000 PRINT=10 METHOD=1 INTER NOABORT
$COVARIANCE
$TABLE ID TIME NOPRINT FILE=BASE


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Received on Wed Apr 09 2008 - 11:27:56 EDT