RE: [NMusers] Population PK Analysis of Simvastatin

Dear Ganesh,

Thank you for your reply and inforamtion. In the said paper, however, the
simvastatin PK was not modeled. Instead, dose-PD relationship was explored.
Thank you again anyway.

More inputs from others are welcome.

Howard



-----Original Message-----
From: Ganesh Mugundu [mailto:mugundgm_at_email.uc.edu]
Sent: Tuesday, April 22, 2008 9:47 PM
To: Howard Lee; NMUSERS_at_GLOBOMAXNM.COM
Subject: Re: [NMusers] Population PK Analysis of Simvastatin

I am not sure if this reference is helpful

Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E,
Lechat P. Use of an indirect effect model to describe the LDL
cholesterol-lowering effect by statins in hypercholesterolaemic patients.
Fundam Clin Pharmacol. 2006 Jun;20(3):321-30.

Ganesh

---------------------------------------
Ganesh M Mugundu
Graduate Student
College of Pharmacy
University of Cincinnati
Cell: 513 417 4847
BLOG: http://pk-pd.blogspot.com/
WebPage: www.geocities.com/ganaish

If you want to get somewhere, you have to know where you want to go and how
to get there. Then NEVER, NEVER, NEVER GIVE UP."

Norman Vincent Peale


Received on Tue Apr 22 2008 - 21:52:29 EDT