RE: [NMusers] Population PK Analysis of Simvastatin

Dear Howard,

In addition to the paper which Ganesh sent you,
this paper will probably be helpful:

Hatanaka T, Honda S, Sasaki S, Katayama K, Koizumi T.
Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibi=
tion of cholesterol synthesis by pravastatin.
J Pharmacokinet Biopharm. 1998 Jun;26(3):329-47.

Best regards
Juergen



-----Ursprüngliche Nachricht-----
Von: "Howard Lee" <leehwd_at_gmail.com>
Gesendet: 23.04.08 03:58:16
An: "'Ganesh Mugundu'" <mugundgm_at_email.uc.edu>
CC: <NMUSERS_at_GLOBOMAXNM.COM>
Betreff: RE: [NMusers] Population PK Analysis of Simvastatin

Dear Ganesh,

Thank you for your reply and inforamtion. In the said paper, however, the=

simvastatin PK was not modeled. Instead, dose-PD relationship was explored=
.
Thank you again anyway.

More inputs from others are welcome.

Howard



-----Original Message-----
From: Ganesh Mugundu [mailto:mugundgm_at_email.uc.edu]
Sent: Tuesday, April 22, 2008 9:47 PM
To: Howard Lee; NMUSERS_at_GLOBOMAXNM.COM
Subject: Re: [NMusers] Population PK Analysis of Simvastatin

I am not sure if this reference is helpful

Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E=
,
Lechat P. Use of an indirect effect model to describe the LDL
cholesterol-lowering effect by statins in hypercholesterolaemic patients.
Fundam Clin Pharmacol. 2006 Jun;20(3):321-30.

Ganesh

---------------------------------------
Ganesh M Mugundu
Graduate Student
College of Pharmacy
University of Cincinnati
Cell: 513 417 4847
BLOG: http://pk-pd.blogspot.com/
WebPage: www.geocities.com/ganaish

If you want to get somewhere, you have to know where you want to go and ho=
w
to get there. Then NEVER, NEVER, NEVER GIVE UP."

Norman Vincent Peale





Received on Tue Apr 22 2008 - 22:14:58 EDT