RE: [NMusers] Population PK Analysis of Simvastatin

Dear Murad,

 

Thank you for the references. Yes, they helped though I am still having
difficulty since no original paper has reported the results of a PK analysis
using the 'population' approach.

 

Regards,

Howard

 

 

  _____

From: Murad Melhem [mailto:melhemmr_at_gmail.com]
Sent: Tuesday, April 22, 2008 11:30 PM
To: Howard Lee
Cc: NMUSERS_at_globomaxnm.com
Subject: Re: [NMusers] Population PK Analysis of Simvastatin

 

Hi Howard,

 

Here are a few references that I am aware of.

 

I hope these help.

 

P.S. The first is a very good review with original refrences cited.

1- Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions
with HMG-CoA reductase inhibitors. Clin Pharmacokinet. 2002;41(5):343-70.

2- Duggan D, Vickers S. Physiological disposition of HMG-CoAreductase
inhibitors. Drug Metab Rev 1990; 22: 333-62.

3- Todd P, Goa K. Simvastatin : a review of its pharmacological properties
and potential in hypercholesterolaemia. Drugs 1990; 40: 583-607.

4- Vickers S, Duncan C, Chen I, et al. Metabolic disposition studies on
simvastatin, a cholesterol-lowering prodrug. Drug Metab Dispos 1990; 18:
138-45.

 

 

Murad Melhem, PhD

Cognigen Corporation

Buffalo, NY

On Tue, Apr 22, 2008 at 9:19 PM, Howard Lee <leehwd_at_gmail.com> wrote:

Dear NMUsers,

 

Is anyone aware of any published population PK analysis of simvastatin?
Either PubMed or google search has resulted in none (I might miss something
out though). In addition, it seems that all statins share this lack of
published population PK information. Any ideas or comments?

 

Thank you,

 

Howard

 

 

 

Howard Lee, MD, PhD

 

Associate Adjunct Professor

Director, Center for Drug Development Science

Department of Biopharmaceutical Sciences

School of Pharmacy

University of California, San Francisco

 

UC Washington Center

1608 Rhode Island Avenue, NW

Washington , DC 20036

Tel: (202)785-5449

Fax: (202)822-5040

Cell: (240)994-8384

Web: http://cdds.ucsf.edu <http://cdds.ucsf.edu/>

Email: <mailto:Howard.Lee_at_ucsf.edu> Howard.Lee_at_ucsf.edu ;
<mailto:leehwd_at_gmail.com> leehwd_at_gmail.com

 

 

 



Received on Wed Apr 23 2008 - 09:25:47 EDT