[NMusers] enzyme turnover

Dear nmuser,

I had analyzed data set of a CYP- inhibitor agent using NONMEM ADVAN 6. A two-comp. model was used to describe the parent and its metabolite data sets sid by side to a hypothetical enzyme compartment. All estimates are fine except the KENZ (enzyme turnover rate was about (2 hr-1) which is 100-fold the published value. my code is

$DES
C2=A(2)/V2 ; for parent
C4=A(4)/V4 ; for metab
DADT(1)= -KA*A(1)
DADT(2)=KA*A(1) - CL24*A(3)*C2
DADT(3)= KENZ - KENZ*A(3) - KIRR *C2 *A(3)
DADT(4)=CL24*A(3)*C2 - CL40*C4

If i use the Emax and IC50 mode, the result is similar. what is wrong with my code ?
All suggesion are wellcome.

Regards
Khaled






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Received on Wed Feb 13 2008 - 08:07:41 EST