Re: [NMusers] Using Prior subroutine

Byung-Jin,

The default NONMEM method puts all its output and run files in the same folder as the control stream file. Experienced NONMEM users find this organization is too simple which prevents such obvious things like running two NONMEM runs at the same time from the same directory.

Both WFN and PSN create run-directories for NM-TRAN/NONMEM to do their work. While this solves the problem of running several simultaneous runs and also organizes the results more clearly (WFN) it brings its own problems for unusual uses which require locating external files such as the PRIOR subroutine.

In your control stream you will have to specify a path to the PRIOR subroutine file so that NM-TRAN can find it from the run-directory.

e.g. for WFN

$SUBR PRIOR=../prior.for

will look for prior.for in the same directory as the control stream file.

PSN has a much more complicated run-directory system and usually (but I dont know for sure always) will need to look 2 levels higher e.g.

$SUBR PRIOR=../../prior.for

WFN (and most likely PSN) will let you use a full path to the file so that it can be located anywhere you want e.g.

$SUBR PRIOR=X:/solarsystem/earth/newzealand/auckland/prior.for

Good luck.

Nick

Byung-Jin Ahn wrote:
>
> Dear all.
>
> To estimate the PK parameters of an antibiotics and define the adequate dose regimen is one of my
>
> present woks.
>
> Because of sparseness of data, I performed the PK analysis using prior subroutine " NWPRI " in
>
> NONMEM(ver 6). and then stabilized estimation of PK parameters could be possible.
>
> However, Wings for NONMEM, Perl-speaks NONMEM as front end of NONMEM did not open or
>
> read the text file including subroutine Prior.
>
> I question whether this problem is a my own problem or general problem.
>
> I wish to hear experiences of this problem.
>
> Sincerly.
>
> Thank you.
>
> Byung-Jin Ahn M.D.
>
> Research Doctor
> CMC Clinical Research Coordinating Center
> College of Medicine, The Catholic University of Korea
> 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Korea
> TEL: +82-2-590-4957 FAX: +82-2-590-7843
> bjahn_at_catholic.ac.kr [Image]

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford_at_auckland.ac.nz tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
Received on Tue Feb 19 2008 - 20:52:15 EST