[NMusers] Is the use of II, SS, and ADDL allowed simultaneously

From: Samtani, Mahesh [PRDUS] <MSamtani_at_prdus.jnj.com>
Date: Wed, 2 Jan 2008 12:43:09 -0500

Dear NMusers,
Is the use of II, SS, and ADDL allowed simultaneously in NONMEM?

I wish to assess PK profiles at SS with and without compliance. Here is =
the potential scenario I am interested in:

i) Patients come in at SS and take their 1st two doses correctly
ii) Patients then remain compliant OR miss a dose OR ingest a double =
dose
iii) Patients then resume taking their doses correctly

For (i) I will need II, SS and ADDL
For (ii) I don't need any II or SS or ADDL
For (iii) I will need II and ADDL

Kindly advice...Mahesh

PS. I am aware that I can hard code (formatting via S-plus etc) each =
dose after the first SS dose as a separate dosing record but I wish to =
know if there is an easier method available



Received on Wed Jan 02 2008 - 12:43:09 EST

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