Re: [NMusers] Is the use of II, SS, and ADDL allowed simultaneously

Hi Mahesh,

For compliant patients, you may use ADDL, II and SS simultaneously.
Assuming you have same dose type (dose, II) for additional doses.
For non-compliant patients who skipped the dose(s), I would add dose event =

record(s) after you the steady state dosing.
For non-compliant patients who doubled the dose(s), then you may use SS=2.

The following is an example I found from Sheiner's training material which =

took place ~10 years ago.

TIME AMT RATE SS II
50 20 . 0 .
64 10 . 2 8


a 10 mg bolus dose every 8 hrs, steady-state at 64 hrs, superimposed on a
20 mg bolus dose at 50 hours.


I hope this helps.


Joseph

Joseph Kim, Ph.D., RPh.
Principal Clinical Pharmacokineticist
CPK/Modelling & Simulation
GlaxoSmithKline
Research Triangle Park
North Carolina 27709
U.S.A.








"Samtani, Mahesh [PRDUS]" <MSamtani_at_prdus.jnj.com>
Sent by: owner-nmusers_at_globomaxnm.com
02-Jan-2008 12:43

 
To
nmusers_at_globomaxnm.com
cc

Subject
[NMusers] Is the use of II, SS, and ADDL allowed simultaneously






Dear NMusers,
Is the use of II, SS, and ADDL allowed simultaneously in NONMEM?
I wish to assess PK profiles at SS with and without compliance. Here is
the potential scenario I am interested in:
i) Patients come in at SS and take their 1st two doses correctly
ii) Patients then remain compliant OR miss a dose OR ingest a double dose
iii) Patients then resume taking their doses correctly
For (i) I will need II, SS and ADDL
For (ii) I don?t need any II or SS or ADDL
For (iii) I will need II and ADDL
Kindly advice?Mahesh
PS. I am aware that I can hard code (formatting via S-plus etc) each dose
after the first SS dose as a separate dosing record but I wish to know if
there is an easier method available



Received on Wed Jan 02 2008 - 14:21:40 EST