[NMusers] NONMEM VI Bug Alert #6

A bug in NM-TRAN has been detected and is described below. Both a
workaround and a
code fix are also described. A fixed routine is available at:
 
ftp://ftp.globomaxnm.com/Public/nonmem/NONMEM_VI_fixed_routines/
<ftp://ftp.globomaxnm.com/Public/nonmem/NONMEM_VI_fixed_routines/> .
Login with
User name:nonmemvi
Password: updates
 
An alternative way to access this directory is to use
 ftp://nonmemvi:updates@ftp.globomaxnm.com/
<ftp://nonmemvi:updates@ftp.globomaxnm.com/>
 
Code changes have been supplied to Metrum Institute for inclusion
in the next release of NMQUAL.
 
A cummulative bug list, NONMEM_VI_1.2_Bug_List.txt, is available at
ftp://ftp.globomaxnm.com/Public/nonmem/NONMEM_VI_buglist/
<ftp://ftp.globomaxnm.com/Public/nonmem/NONMEM_VI_buglist/>
 
At the time these fixes are incorporated into NONMEM VI 1.2 we recommend
changing the value of LEV in BLKDAT to 1.3.
 
NM-TRAN code
 
7. This bug affects only NONMEM VI.
 
   The bug affects $ERROR abbreviated code of the form
     IF (condition) V=expression
   or
     IF (condition) THEN
     V=expression
     ENDIF
   when all of the following are true of at least one variable X:
   1) X appears in both the condition and the expression;
   2) X is defined in $PK
   3) X has partials wrt. ETAs.
 
   The bug causes the partials of X to be ignored.
   If V (and therefore X) affects the objective function, then the
   value of the objective function is incorrect.
 
   Workaround:
   Assign the variable from $PK (or the complete expression that uses
   variables from $PK) to a variable that is local to $ERROR.
 
   E.g.,
    Instead of
       IF (A(1)/V1.GT.0) TY=A(1)/V1
    Use
       C1=A(1)/V1
       IF (C1.GT.0) TY=C1
 
   Fix:
   In routine GETLOG, locate
   C ALSO DO THIS IF IN INITIALIZATION-FINALIZATION BLOCK 8/00
   Insert after it:
     IF (NTYP.EQ.2) THEN
   Locate the following 6 lines down:
     IPOS=NTEMP
   Insert after it:
      ENDIF


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Received on Thu Jan 17 2008 - 09:29:08 EST