[NMusers] data splitting/interoccasion variability

Dear NMUSERS,

 

I have some questions on data splitting/interoccasion variability. I have
Carboplatin PK data from 69 Patients from different studies. 9 of these
patients were observed on more than 1 cycle (7 Patients 2 cycles, 1 Patient
3 cycles, 1 Patient 4 cycles). On all occasions (cycles) full sampling was
performed.

 

1) Will estimation of IOV be successful with data from only 12 additional
cycles?

 

2) How should the dataset be spitted in order to perform an internal
"validation" (e.g. leaving all the data from the 9 patients with several
occasions in the model development set + a random sample out of the
remaining 60 patients?).

 

I am looking forward to your comments.

 

Best regards, Andreas.

 

____________________________

 

Andreas Lindauer

 

University of Bonn

Department of Clinical Pharmacy

An der Immenburg 4

D-53121 Bonn

 

phone:+49 228 73 5781

fax: +49 228 73 9757

 



Received on Thu Jan 24 2008 - 09:10:07 EST