Re: [NMusers] Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM

Dear Winnie,

it is not advisable to "normalize" the data to body weight or body
surface area.
Instead, you should build a basic model without weight/BSA and try to
use weight or BSA as covariate for the pharmacokinetic parameters. Also,
you should test the allometric scaling approach (see Anderson et al.
Clin Pharmacokin 33(5): 313-327 (1997).

With best regards

Georg

--
Hochschuldozent Dr. Georg Hempel
Institut fuer Pharmazeutische und Medizinische Chemie
- Klinische Pharmazie -
Hittorfstr. 58-62
48149 Muenster, Germany
E-mail: georg.hempel_at_uni-muenster.de
Received on Wed Mar 26 2008 - 06:39:40 EDT