[NMusers] 95% CI from NONMEM

Hello all, I need help calculating 95% confidence interval from
NONMEM. Is mean±2SD accurate? or some paper mentioned use simulation
1000 times to get 95% CI, I just do not know how to do it.

In addition, I have 4 different treatment groups, should I model them
separately and get predicted concentration and PK parameters, then
compared the statistically difference among these parameters, Or
should I group them together and set a covariance, see if the
covariance model has much lower OFV than base model.

Thank you,
Received on Thu May 15 2008 - 15:51:47 EDT