Re: [NMusers] free AUC

Hi Kalan,
The answer is a bit more involved and requires additional information, such as the route of administration (i.e.- IV vs. oral) and information relating to the hepatic extraction ratio for the drug. In short, I'd recommend reviewing a thorough presentation of the derivation in Rowland and Tozer's "Clinical Pharmacokinetics: Concepts and Applications" + a presentation available at: www.uiowa.edu/~c046138/CLh.ppt

Regards,
Matt
~~~~~~~~~~~~~~~~~~~
Matthew M. Riggs, Ph.D.
Metrum Research Group LLC
mattr_at_metrumrg.com


----- Original Message ----
From: Khaled Nm <khal_nm_at_yahoo.com>
To: nmusers_at_globomaxnm.com
Sent: Wednesday, May 21, 2008 9:25:55 AM
Subject: [NMusers] free AUC


Dear nmusers,

If i have only the AUC of a drug. Can I calculate the fAUC using the equation: fAUC=AUC * f ? where f stands for the free fraction of the drug ?
Is there another solution ?

Regards
Kalan


      
Received on Wed May 21 2008 - 10:55:35 EDT