Hello
You can calculate free AUC, as you have described, only if the relationship
between total and free concentration is linear and the free fraction remain
constant throughout the dosing interval.
Fatemeh
>===== Original Message From Khaled Nm <khal_nm_at_yahoo.com> =====
>Dear nmusers,
>
>If i have only the AUC of a drug. Can I calculate the fAUC using the
equation: fAUC=AUC * f ? where f stands for the free fraction of the drug ?
>Is there another solution ?
>
>Regards
>Kalan
Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA
Phone/Fax: (401) 874 9205/(401) 874 2181
Email: fatemeh_at_uri.edu
Laboratory Website: http://www.uri.edu/pharmacy/faculty/aps/akhlaghi/index
Received on Wed May 21 2008 - 11:31:56 EDT
This archive was generated by hypermail 2.2.0 : Thu May 22 2008 - 11:22:54 EDT